From world-leading scientist and New York Times bestselling author of The Language of God, a deeply thoughtful guidebook to discerning what and who we can trust to move us from societal discord to civic harmony. As the COVID-19 pandemic revealed, western society has become not just hyper-partisan, but also deeply cynical; distrustful of traditional sources of knowledge and wisdom such as science and faith. Scepticism about vaccines led to the needless deaths of at least 230,000 Americans, and “Do your own research” is now a rallying cry in many online rabbit holes. Yes, experts can make mistakes, and institutions can lose their moral compass, but there are reliable ways and means to weigh information and navigate truth, and The Road to Wisdom is here to help us rediscover them. Francis Collins reminds us of the four core sources of judgement and clear thinking: truth, science, faith, and trust. Drawing on his scientific work at the forefront of the Human Genome Project and the US National Institutes of Health, as well as on ethics, philosophy, and theology, Collins makes a robust, thoughtful case for each of these sources, their reliability, and their limits. Ultimately, he shows how they work together, not separately and certainly not in conflict. It is only when we re-link these four pillars of wisdom that we can begin to discern the best path forward in life.