Rachel, a brilliant organic chemist and Sam, her husband find themselves ensnared in a web of ambition, addiction & dangerous secrets. When they strike a Faustian deal with the enigmatic Massey Mancuso to create the ultimate recreational drug, their lives take a perilous turn. As they journey deep into this capricious world, they face betrayals, violence and startling revelations that confront their reality. U explores the seductive power of science and hedonism and the morally ambiguous world of drug development in the overlap between Big Pharma and the criminal underworld.